Evolence™ - Dermal Fillers

The manufacturers of this product, Johnson & Johnson, announced in November 2009 that they had ceased production of EVOLENCE. They went on to say that they were still going to be available for any sort of assistance regarding use of products that had already been purchased by practitioners. They assured consumers that they will remain active in support of any effects reported and confirmed that the usage dates displayed on the products and all bindings will remain active.

The product was launched in the UK market at the beginning of 2005 as a collagen-based dermal filler. It was originally by ColBar LifeScience which later became part of the Johnson & Johnson Company. The original launching took place in Europe in 2004 during the EADV congress in Florence, Italy. Evolence was created to treat soft tissue deficiencies like scars, nasolabial folds and wrinkles. The application of Evolence is done in single-us syringes and contains 1ml, equivalent to 35mg/ml of porcine collagen - highly purified and crosslinked. It is dispersed in a saline solution that is buffered by phosphate. The collagen that is found in Evolence is derived from porcine tendons (pig). The degree of compatibility with the human body is very high, thus making it possible to use the product in human medicine involving operations like replacement of heart valves, surgical wound dressings and implantable lenses.

The processing of the product during manufacturing is patented Glymatrix™ technology. It is done by first breaking down the source material into tiny molecules, followed by creation of strong natural bonds through use of ribose, a naturally available sugar. This process gives collagen, which is enough to be used in filling very deep contours on the face. This is achieved instantly and the high viscosity of the substance makes it easy for injection. Testing before treatment is not required given the natural characteristics of the product and the effective natural based technology.

Evolence is temporary but, according to the manufacturers, it can last for up to 12 months before reapplication is needed. Expected side effects that are likely to be experienced include bruising and bleeding; with the injection likely to give rise to some uncomfortable feeling but this can be conveniently controlled by use of anesthetic cream before having the treatment. Mild swelling or itching can also be experienced a few days after treatment.